P21 activated kinase-1 (PAK1) in macrophages is required for promotion of Th17 cell response during helminth infection.

ABSTRACT: CD4⁺ T cells differentiate into distinct functional effector and inhibitory subsets are facilitated by distinct cytokine cues present at the time of antigen recognition. Maintaining a balance between T helper 17 (Th17) and regulatory T (Treg) cells are critical for the control of the immunopathogenesis of liver diseases. Here, by using the mouse model of helminth Schistosoma japonicum (S japonicum) infection, we show that the hepatic mRNA levels of P21-activated kinase 1 (PAK1), a key regulator of the actin cytoskeleton, adhesion and cell motility, are significantly increased and associated with the development of liver pathology during S japonicum infection. In addition, PAK1-deficient mice are prone to suppression of Th17 cell responses but increased Treg cells. Furthermore, P

SUBMITTER: Chang H 

PROVIDER: S-EPMC7753984 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature