Neurexin-2 is a potential regulator of inflammatory pain in the spinal dorsal horn of rats.

ABSTRACT: Chronic pain is one of the serious conditions that affect human health and remains cure still remains a serious challenge as the molecular mechanism remains largely unclear. Here, we used label-free proteomics to identify potential target proteins that regulate peripheral inflammatory pain and reveal its mechanism of action. Inflammation in peripheral tissue was induced by injecting complete Freund's adjuvant (CFA) into rat hind paw. A proteomic method was adopted to compare the spinal dorsal horn (SDH) in peripheral inflammatory pain (PIP) model rats with controls. Differential proteins were identified in SDH proteome by label-free quantification. The role of screened target proteins in the PIP was verified by small interfering RNA (siRNA). A total of 3072 and 3049 proteins were identifie

SUBMITTER: Xu L 

PROVIDER: S-EPMC7754071 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature