Assessment of Botulinum Neurotoxin Injection for Dystonic Hand Tremor: A Randomized Clinical Trial.

ABSTRACT:

Importance

There is an unmet need for safe and efficacious treatments for upper-extremity dystonic tremor (DT). To date, only uncontrolled retrospective case series have reported the effect of botulinum neurotoxin (BoNT) injections on upper-extremity DT.

Objective

To assess the effect of BoNT injections on tremor in patients with upper-extremity DT.

Design, setting, and participants

In this placebo-controlled, parallel-group randomized clinical trial, 30 adult patients with upper-extremity DT treated at a movement disorder clinic in a tertiary care university hospital were randomized in a 1:1 ratio to BoNT or saline injection, 0.9%, using a computer-generated randomization sequence. Randomization was masked using opaque envelopes. The participant, injector, outcome as

SUBMITTER: Rajan R 

PROVIDER: S-EPMC7754081 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature