Prognostic significance of immunohistochemical markers and histological classification in malignant canine mammary tumours.

ABSTRACT: Canine mammary carcinoma represents a model for the study of human breast cancer, although the prognostic value of various clinical, histological and immunohistochemical parameters has shown contradictory results. A prospective study, through a 4-year follow-up, was performed in 77 patients with mammary carcinoma to analyse the association between histological diagnosis, grade of malignancy, peritumoral and vascular invasion. We have also performed immunohistochemistry for the expression of oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and cyclooxygenase-2 (COX-2) that define human biomarkers of disease progression and treatment response. An association between histological diagnosis and clinical stage was observed with a high proporti

SUBMITTER: Pastor N 

PROVIDER: S-EPMC7754150 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature