Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.

ABSTRACT:

Objective

Hypertension is associated with renal immune cell accumulation and sodium retention. Lymphatic vessels provide a route for immune cell trafficking and fluid clearance. Whether specifically increasing renal lymphatic density can treat established hypertension, and whether renal lymphatics are involved in mechanisms of blood pressure regulation remain undetermined. Here, we tested the hypothesis that augmenting renal lymphatic density can attenuate blood pressure in established hypertension.

Methods

Transgenic mice with inducible kidney-specific overexpression of VEGF-D ('KidVD+' mice) and KidVD- controls were administered a nitric oxide synthase inhibitor, L-NAME, for 4 weeks, with doxycycline administration beginning at the end of week 1. To identify mechanisms by

SUBMITTER: Balasubbramanian D 

PROVIDER: S-EPMC7754173 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature