Toll-like receptor 2 activation induces C-C chemokine receptor 2-dependent natural killer cell recruitment to the peritoneum.

ABSTRACT: Natural killer (NK) cells are innate effector cells with critical roles not only in tumor immunosurveillance and viral immunity, but also in bacterial and fungal infections. Toll-like receptor 2 (TLR2) can be important in the early and sustained immune responses to pathogens and tumors through the induction of cytokines and chemokines that recruit and activate immune effector cells. We investigated the role of TLR2 activation in NK cell recruitment with a view to informing approaches to induce or regulate peritoneal NK cell responses therapeutically. Peritoneal injection of TLR2 activators, including peptidoglycan and the lipopeptides FSL-1 and Pam₃ CSK₄ , resulted in NK cell recruitment after 16 h with increased NK cell numbers maintained for 48 h. TLR2 activators in

SUBMITTER: Haidl ID 

PROVIDER: S-EPMC7754274 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature