Development of the Scalp Hair Assessment PRO™ measure for alopecia areata.

ABSTRACT:

Background

Valid patient-reported outcome (PRO) measures are required to evaluate alopecia areata (AA) treatments.

Objectives

To develop a content-valid and clinically meaningful PRO measure to assess AA scalp hair loss with scores comparable with the five-response-level Alopecia Areata Investigator Global Assessment (AA-IGA™).

Methods

A draft PRO measure was developed based on input from 10 clinical experts in AA. The PRO measure was cognitively debriefed, modified and finalized through two rounds of qualitative semistructured interviews with patients with AA who had experienced ≥ 50% scalp hair loss. Data were thematically analysed.

Results

Adults (round 1: n = 25; round 2: n = 15) and adolescents aged 15-17 years (round 1: n = 5) in North America participate

SUBMITTER: Wyrwich KW 

PROVIDER: S-EPMC7754291 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature