Zinc modulation of proton currents in a new voltage-gated proton channel suggests a mechanism of inhibition.

ABSTRACT: The H_V 1 voltage-gated proton (H_V 1) channel is a key component of the cellular proton extrusion machinery and is pivotal for charge compensation during the respiratory burst of phagocytes. The best-described physiological inhibitor of H_V 1 is Zn²⁺ . Externally applied ZnCl₂ drastically reduces proton currents reportedly recorded in Homo sapiens, Rattus norvegicus, Mus musculus, Oryctolagus cuniculus, Rana esculenta, Helix aspersa, Ciona intestinalis, Coccolithus pelagicus, Emiliania huxleyi, Danio rerio, Helisoma trivolvis, and Lingulodinium polyedrum, but with considerable species variability. Here, we report the effects of Zn²⁺ and Cd²⁺ on H_V 1 from Nicoletia phytophila, NpH_V 1. We introdu

SUBMITTER: Chaves G 

PROVIDER: S-EPMC7754295 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature