A noninterventional, multinational study to assess PD-L1 expression in cytological and histological lung cancer specimens.

ABSTRACT:

Background

The diagnosis of advanced lung cancer is made with minimally invasive procedures. This often results in the availability of cytological material only for subtype determination and companion diagnostic testing, with the latter being technically and clinically validated on histological material only. Thus, the primary objective of the MO29978 clinical study was to assess programmed death ligand 1 (PD-L1) protein expression on cytology samples as surrogates for histology samples in patients with lung cancer.

Methods

Formalin-fixed, paraffin-embedded histological samples and cytological cell blocks from 190 patients were analyzed with immunohistochemical assays using the rabbit monoclonal anti-PD-L1 antibody clones SP142 and SP263. PD-L1 expression was quantified on b

SUBMITTER: Bubendorf L 

PROVIDER: S-EPMC7754298 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature