A chromosome-scale reference genome and genome-wide genetic variations elucidate adaptation in yak.

ABSTRACT: Yak is an important livestock animal for the people indigenous to the harsh, oxygen-limited Qinghai-Tibetan Plateau and Hindu Kush ranges of the Himalayas. The yak genome was sequenced in 2012, but its assembly was fragmented because of the inherent limitations of the Illumina sequencing technology used to analyse it. An accurate and complete reference genome is essential for the study of genetic variations in this species. Long-read sequences are more complete than their short-read counterparts and have been successfully applied towards high-quality genome assembly for various species. In this study, we present a high-quality chromosome-scale yak genome assembly (BosGru_PB_v1.0) constructed with long-read sequencing and chromatin interaction technologies. Compared to an existing yak genom

SUBMITTER: Ji QM 

PROVIDER: S-EPMC7754329 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature