Key Opportunities to Replace, Reduce, and Refine Regulatory Fish Acute Toxicity Tests.

ABSTRACT: Fish acute toxicity tests are conducted as part of regulatory hazard identification and risk-assessment packages for industrial chemicals and plant protection products. The aim of these tests is to determine the concentration which would be lethal to 50% of the animals treated. These tests are therefore associated with suffering in the test animals, and Organisation for Economic Co-operation and Development test guideline 203 (fish, acute toxicity) studies are the most widely conducted regulatory vertebrate ecotoxicology tests for prospective chemical safety assessment. There is great scope to apply the 3Rs principles-the reduction, refinement, and replacement of animals-in this area of testing. An expert ecotoxicology working group, led by the UK National Centre for the Replacement, Refin

SUBMITTER: Burden N 

PROVIDER: S-EPMC7754335 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature