Tryptophan Metabolites Are Associated With Symptoms and Nigral Pathology in Parkinson's Disease.

ABSTRACT:

Background

The objective of this study was to determine whether neurotoxic kynurenine metabolites, induced by inflammation, in plasma and cerebrospinal fluid (CSF) are associated with symptom severity and nigral pathology in Parkinson's disease (PD).

Methods

Clinical and MRI data were obtained from 97 PD and 89 controls. We used ultra-performance liquid chromatography to quantify kynurenine metabolites and high-sensitivity multiplex assays to quantify inflammation in plasma and CSF. We evaluated group-wise differences as well as associations between the biomarkers, motor and nonmotor symptoms, and nigral R2* (MRI metric reflecting iron content).

Results

PD subjects had >100% higher 3-hydroxykynurenine and 14% lower 3-hydroxyanthranilic acid in plasma. The 3-HK in plas

SUBMITTER: Heilman PL 

PROVIDER: S-EPMC7754343 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature