Risk of severe hypoglycaemia and its impact in type 2 diabetes in DEVOTE.

ABSTRACT:

Aims

To undertake a post-hoc analysis, utilizing a hypoglycaemia risk score based on DEVOTE trial data, to investigate if a high risk of severe hypoglycaemia was associated with an increased risk of cardiovascular events, and whether reduced rates of severe hypoglycaemia in patients identified as having the highest risk affected the risk of cardiovascular outcomes.

Materials and methods

The DEVOTE population was divided into quartiles according to patients' individual hypoglycaemia risk scores. For each quartile, the observed incidence and rate of severe hypoglycaemia, major adverse cardiovascular event (MACE) and all-cause mortality were determined to investigate whether those with the highest risk of hypoglycaemia were also at the greatest risk of MACE and all-cause mortal

SUBMITTER: Heller S 

PROVIDER: S-EPMC7754351 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature