Relation between sex hormones and leucocyte telomere length in men with idiopathic pulmonary fibrosis.

ABSTRACT:

Background and objective

IPF is an ageing-related lung disorder featuring progressive lung scarring. IPF patients are frequently identified with short telomeres but coding mutations in telomerase can only explain a minority of cases. Sex hormones regulate telomerase activity in vitro and levels of sex hormones are related to LTL. The objective of this study was to explore whether sex hormones were associated with LTL, whether they interacted with genetic variants in telomerase and whether polymorphisms in the exon of androgen metabolism genes were associated with plasma testosterone concentrations in male IPF patients.

Methods

A case-control study was performed on 101 male IPF subjects and 51 age-matched healthy controls. Early morning plasma sex hormones were quantified, an

SUBMITTER: Fang C 

PROVIDER: S-EPMC7754418 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature