Establishing Ghanaian adult reference intervals for hematological parameters controlling for latent anemia and inflammation.

ABSTRACT:

Background

In Ghana, diagnostic laboratories rely on reference intervals (RIs) provided by manufacturers of laboratory analyzers which may not be appropriate. This study aimed to establish RIs for hematological parameters in adult Ghanaian population.

Methods

This cross-sectional study recruited 501 apparently healthy adults from two major urban areas in Ghana based on the protocol by IFCC Committee for Reference Intervals and Decision Limits. Whole blood was tested for complete blood count (CBC) by Sysmex XN-1000 analyzer, sera were tested for iron and ferritin by Beckman-Coulter/AU480, for transferrin, vitamin-B12, and folate was measured by Centaur-XP/Siemen. Partitioning of reference values by sex and age was guided by "effect size" of between-subgroup differences define

SUBMITTER: Bawua ASA 

PROVIDER: S-EPMC7754426 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature