Evaluation of 10 years of parainfluenza virus, human metapneumovirus, and respiratory syncytial virus infections in lung transplant recipients.

ABSTRACT: Respiratory tract infection with pneumoviruses (PVs) and paramyxoviruses (PMVs) are increasingly associated with chronic lung allograft dysfunction (CLAD) in lung transplant recipients (LTRs). Ribavirin may be a treatment option but its effectiveness is unclear, especially with respect to infection severity. We retrospectively analyzed 10 years of PV/PMV infections in LTRs. The main end points were forced expiratory volume in 1 second (FEV₁ ) at 3 and 6 months postinfection, expressed as a percentage of pre-infection FEV₁ and incidence of new or progressed CLAD 6 months postinfection. A total of 139 infections were included: 88 severe infections (63%) (defined as >10% FEV₁ loss at infection) and 51 mild infections (37%) (≤10% FEV₁ loss). Overall

SUBMITTER: de Zwart AES 

PROVIDER: S-EPMC7754441 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature