Risk of hematological malignancy in blood donors: A nationwide cohort study.

ABSTRACT:

Background

There has been a concern that blood donations can increase the risk of hematological malignancies. We investigated if blood donations increase the risk of developing hematological malignancies, specifically acute lymphoblastic leukemia, acute myeloid leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myeloid leukemia, Hodgkin lymphoma, and myeloma, as well other non-Hodgkin lymphoma.

Study design and methods

In total, the study included 1,021,433 Swedish blood donors, with 19.5 million person-years of follow-up. Two sets of analysis were performed. In the first cohort analysis, standardized incidence ratios (SIRs) were calculated, comparing the incidence of the different types of hematological cancers in blood donors to that of the general population. In

SUBMITTER: Zhao J 

PROVIDER: S-EPMC7754460 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature