Three-dimensional reconstruction of porous polymer films from FIB-SEM nanotomography data using random forests.

ABSTRACT: Combined focused ion beam and scanning electron microscope (FIB-SEM) tomography is a well-established technique for high resolution imaging and reconstruction of the microstructure of a wide range of materials. Segmentation of FIB-SEM data is complicated due to a number of factors; the most prominent is that for porous materials, the scanning electron microscope image slices contain information not only from the planar cross-section of the material but also from underlying, exposed subsurface pores. In this work, we develop a segmentation method for FIB-SEM data from ethyl cellulose porous films made from ethyl cellulose and hydroxypropyl cellulose (EC/HPC) polymer blends. These materials are used for coating pharmaceutical oral dosage forms (tablets or pellets) to control drug release. We

SUBMITTER: ROding M 

PROVIDER: S-EPMC7754501 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature