Silent cerebral infarcts in patients with sickle cell disease: a systematic review and meta-analysis.

ABSTRACT:

Background and purpose

Silent cerebral infarcts (SCIs) are the most common neurological complication in children and adults with sickle cell disease (SCD). In this systematic review, we provide an overview of studies that have detected SCIs in patients with SCD by cerebral magnetic resonance imaging (MRI). We focus on the frequency of SCIs, the risk factors involved in their development and their clinical consequences.

Methods

The databases of Embase, MEDLINE ALL via Ovid, Web of Science Core Collection, Cochrane Central Register of Trials via Wiley and Google Scholar were searched from inception to June 1, 2019.

Results

The search yielded 651 results of which 69 studies met the eligibility criteria. The prevalence of SCIs in patients with SCD ranges from 5.6 to 80.6%

SUBMITTER: Houwing ME 

PROVIDER: S-EPMC7754589 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature