Advantages of visualisations to evaluate and communicate adverse event information in randomised controlled trials.

ABSTRACT:

Background

Randomised controlled trials (RCTs) provide valuable information and inform the development of harm profiles of new treatments. Harms are typically assessed through the collection of adverse events (AEs). Despite AEs being routine outcomes collected in trials, analysis and reporting of AEs in journal articles are continually shown to be suboptimal. One key challenge is the large volume of AEs, which can make evaluation and communication problematic. Prominent practice is to report frequency tables of AEs by arm. Visual displays offer an effective solution to assess and communicate complex information; however, they are rarely used and there is a lack of practical guidance on what and how to visually display complex AE data.

Methods

In this article, we demonstrate

SUBMITTER: Cornelius V 

PROVIDER: S-EPMC7754702 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature