Associations between cytokine gene polymorphisms and rheumatoid arthritis in Turkish population.

ABSTRACT:

Objective

Various cytokine polymorphisms have been associated with genetic risk factors predisposing to Rheumatoid Arthritis (RA) in different populations. To predict the clinical outcome as well as response to therapy in RA, studies aimed to describe genetic markers. The present study aims to search for polymorphisms of 13 cytokine coding genes in the Eastern Black Sea Region of Turkey.

Methods

DNAs of 49 patients and 96 healthy bone marrow and kidney donors were isolated from peripheral blood samples. Genotyping was performed using the Heidelberg Cytokine Typing Tray kit. PCR products were visualized on an agarose gel, and results were analyzed using the interpretation scheme provided with the kit. Arlequin 3.5 software was used for statistical analysis.

Results

No

SUBMITTER: Yucel B 

PROVIDER: S-EPMC7754868 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature