The role of NO in COVID-19 and potential therapeutic strategies.

ABSTRACT: Nitric oxide (NO) is a free radical playing an important pathophysiological role in cardiovascular and immune systems. Recent studies reported that NO levels were significantly lower in patients with COVID-19, which was suggested to be closely related to vascular dysfunction and immune inflammation among them. In this review, we examine the potential role of NO during SARS-CoV-2 infection from the perspective of the unique physical, chemical and biological properties and potential mechanisms of NO in COVID-19, as well as possible therapeutic strategies using inhaled NO. We also discuss the limits of NO treatment, and the future application of this approach in prevention and therapy of COVID-19.

SUBMITTER: Fang W 

PROVIDER: S-EPMC7754882 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature