Cardiopoietic stem cell therapy in ischaemic heart failure: long-term clinical outcomes.

ABSTRACT:

Aims

This study aims to explore long-term clinical outcomes of cardiopoiesis-guided stem cell therapy for ischaemic heart failure assessed in the Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-1) trial.

Methods and results

CHART-1 is a multinational, randomized, and double-blind trial conducted in 39 centres in heart failure patients (n = 315) on standard-of-care therapy. The 'active' group received cardiopoietic stem cells delivered intramyocardially using a retention-enhanced catheter. The 'control' group underwent patient-level sham procedure. Patients were followed up to 104 weeks. In the entire study population, results of the primary hierarchical composite outcome were maintained neutral at Week 52 [Mann-Whitney estimator 0.52, 95% confidence interv

SUBMITTER: Bartunek J 

PROVIDER: S-EPMC7754898 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature