Identification of physiologic treatment targets with favourable haemodynamic consequences in heart failure with preserved ejection fraction.

ABSTRACT:

Aims

Heart failure with preserved ejection fraction (HFpEF) is characterized by complex pathophysiology including an impaired diastolic reserve. We recently showed that milrinone favourably modifies filling pressures at rest and during exertion in HFpEF patients; however, the responsible mechanism is uncertain. The objective of this study was to develop a clearer understanding of the acutely modifiable physiologic parameters that may be targeted in HFpEF.

Methods and results

We conducted computer modelling simulations based on invasive haemodynamic assessments, by right heart catheterization, in HFpEF patients at baseline and in response to milrinone. Our aim was to develop a detailed understanding of the physiologic mechanisms, which accounted for the observed actions. The

SUBMITTER: Kaye DM 

PROVIDER: S-EPMC7754909 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature