Nitrates in combination with hydralazine in cardiorenal syndrome: a randomized controlled proof-of-concept study.

ABSTRACT:

Aims

Cardiorenal syndrome (CRS) is a common problem of great morbidity and mortality. Hydralazine-isosorbide dinitrate (H-ISDN) may be used in renal failure and may improve exercise capacity in heart failure (HF). Our proof-of-concept study aimed to evaluate early evidence of efficacy, safety, and feasibility of H-ISDN compared with standard of care in CRS.

Methods and results

This multi-centre, single-blind, randomized trial in Singapore enrolled CRS patients, defined as chronic HF with concomitant renal failure [estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m² ]. The primary outcome was 6 min walk test (6MWT) distance measured at 6 months. Secondary outcomes included study feasibility; efficacy outcomes which included renal, cardiac, and endotheli

SUBMITTER: Lim SL 

PROVIDER: S-EPMC7754984 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature