Early benefits of empagliflozin in patients with or without heart failure: findings from EMPA-REG OUTCOME.

ABSTRACT:

Aims

The EMPA-REG OUTCOME trial demonstrated reductions in cardiovascular (CV) death and heart failure (HF) outcomes with empagliflozin, a sodium-glucose co-transporter 2 inhibitor, in patients with type 2 diabetes and established CV disease over a study period of 3 years. We aimed to investigate the early benefit-risk profile of empagliflozin in patients enrolled in the EMPA-REG OUTCOME trial according to HF status at baseline.

Methods and results

The effects of treatments on glycated haemoglobin, systolic blood pressure and body weight, and on the HF endpoints of hospitalization for HF (HHF), HHF or CV death, and HHF or all-cause mortality were evaluated at 12 weeks, 6 months, and 1 year after randomization. Occurrence of adverse events (AEs) during these time points was a

SUBMITTER: Pellicori P 

PROVIDER: S-EPMC7754994 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature