Association of rs2070600 in advanced glycosylation end-product specific receptor with prognosis of heart failure.

ABSTRACT:

Aims

Our objective was to investigate the association of common variants in the coding region of advanced glycosylation end-product specific receptor (RAGE) and the prognosis of heart failure (HF).

Methods and results

A total of 3394 HF patients were continuously enrolled from January 2009 to August 2018 with a median follow-up of 20.4 months. Additionally, 2861 healthy subjects also participated in the study. By sequencing these two groups, we identified a common functional missense variant rs2070600 in the coding region of RAGE, which showed a significant association with the prognosis of HF [hazard ratio = 0.53, 95%, confidence interval (CI) = 0.30-0.94, P = 0.03], but no association with the risk of HF (odds ratio = 0.52, 95%, CI = 0.66-1.04, P = 0.106). A series of func

SUBMITTER: Li S 

PROVIDER: S-EPMC7755010 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature