A 3 year post-intervention follow-up on mortality in advanced heart failure (EVITA vitamin D supplementation trial).

ABSTRACT:

Aims

Vitamin D supplementation is widely used in the clinical setting, but its effects on mortality and cardiovascular outcomes in patients with heart failure are unclear. This paper reports outcome data that were collected during follow-up of 3 years after closure of the EVITA trial (a 3 year randomized, placebo-controlled, intervention study with 4000 IU vitamin D daily in patients with advanced heart failure), to capture potential latency effects of vitamin D supplementation on clinical outcomes.

Methods and results

The prespecified primary endpoint was overall mortality. Secondary endpoints included hospitalization, mechanical circulatory support implantation, high urgent listing for heart transplantation, and heart transplantation. For group comparisons, we used Cox reg

SUBMITTER: Zittermann A 

PROVIDER: S-EPMC7755020 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature