Update in clinical and mouse microbiota research in allogeneic haematopoietic cell transplantation.

ABSTRACT:

Purpose of review

The intestinal microbiota plays a critical role in intestinal homeostasis and immune regulation and has been recognized as a predictor of clinical outcome in patients undergoing allogeneic haematopoietic cell transplantation (allo-HCT) and specifically a determinant of the severity of graft-versus-host disease (GVHD) in mouse models. As GVHD is the most important cause of nonrelapse mortality (NRM) after allo-HCT, understanding the mechanisms by which modifying the microbiota may prevent or decrease the severity of GVHD would represent an important advance.

Recent findings

Microbiota injury was observed globally and higher diversity at peri-engraftment was associated with lower mortality. Lactose is a dietary factor that promotes post-allo-HCT Enterococcus

SUBMITTER: Lindner S 

PROVIDER: S-EPMC7755070 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature