Collimatorless Scintigraphy for Imaging Extremely Low Activity Targeted Alpha Therapy (TAT) with Weighted Robust Least Squares (WRLS).

ABSTRACT: A technology for imaging extremely low photon flux is an unmet need, especially in targeted alpha therapy (TAT) imaging, which requires significantly improved sensitivity to detect as many photons as possible while retaining a reasonable spatial resolution. In scintigraphy using gamma cameras, the radionuclide collimator rejects a large number of photons that are both primary photons and scattered photons, unsuitable for photon-starved imaging scenarios like imaging TAT. In this paper we develop a min-min weighted robust least squares (WRLS) algorithm to solve a general reconstruction problem with uncertainties and validate it with the extreme scenario: collimatorless scintigraphy. Ra-223, a therapeutic alpha emitting radionuclide whose decay chain includes x-ray and gamma-ray photons, is

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC7755096 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature