A critical role for CARD9 in pneumocystis pneumonia host defence.

ABSTRACT: Caspase recruitment domains-containing protein 9 (CARD9) is an adaptor molecule critical for key signalling pathways initiated through C-type lectin receptors (CLRs). Previous studies demonstrated that Pneumocystis organisms are recognised through a variety of CLRs. However, the role of the downstream CARD9 adaptor signalling protein in host defence against Pneumocystis infection remains to be elucidated. Herein, we analysed the role of CARD9 in host defence against Pneumocystis both in CD4-depleted CARD9^-/- and immunocompetent hosts. Card9 gene-disrupted (CARD9^-/- ) mice were more susceptible to Pneumocystis, as evidenced by reduced fungal clearance in infected lungs compared to wild-type (WT) infected mice. Our data suggests that this defect was due to impaired proi

SUBMITTER: Kottom TJ 

PROVIDER: S-EPMC7755114 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature