Dataset Information

The complete mitochondrial genome of a yellow-bellied sea snake (Hydrophis platurus) (Squamata, Elapidae).

ABSTRACT: In this study, we provide the first report of the complete mitochondrial genomic sequencing of a yellow-bellied sea snake (Hydrophis platurus) that has the broadest distribution range of all Squamata species. The mitogenome length was 18,101 bp and consisted of 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes, and 3 non-coding regions. The sequence presented could be very useful for further phylogenetic and evolutionary studies.

SUBMITTER: Kim JG

PROVIDER: S-EPMC7755313 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

The complete mitochondrial genome of a yellow-bellied sea snake (<i>Hydrophis platurus</i>) (Squamata, Elapidae).

Kim Jong-Gwan JG Park Jaejin J Yi Chang-Ho CH Kim Min-Seop MS Cho In-Young IY Kim Ji Min JM Kim Il-Hun IH

Mitochondrial DNA. Part B, Resources 20200127 1

In this study, we provide the first report of the complete mitochondrial genomic sequencing of a yellow-bellied sea snake (<i>Hydrophis platurus</i>) that has the broadest distribution range of all Squamata species. The mitogenome length was 18,101 bp and consisted of 13 protein-coding genes, 2 rRNA genes, 22 tRNA genes, and 3 non-coding regions. The sequence presented could be very useful for further phylogenetic and evolutionary studies. ...[more]

PMID: 33426277

Similar Datasets

Project description:BackgroundA comprehensive evaluation of the -omic profiles of venom is important for understanding the potential function and evolution of snake venom. Here, we conducted an integrated multi-omics-analysis to unveil the venom-transcriptomic and venomic profiles in a same group of spine-bellied sea snakes (Hydrophis curtus) from the South China Sea, where the snake is a widespread species and might generate regionally-specific venom potentially harmful to human activities. The capacity of two heterologous antivenoms to immunocapture the H. curtus venom was determined for an in-depth evaluation of their rationality in treatment of H. curtus envenomation. In addition, a phylogenetic analysis by maximum likelihood was used to detect the adaptive molecular evolution of full-length toxin-coding unigenes.ResultsA total of 90,909,384 pairs of clean reads were generated via Illumina sequencing from a pooled cDNA library of six specimens, and yielding 148,121 unigenes through de novo assembly. Sequence similarity searching harvested 63,845 valid annotations, including 63,789 non-toxin-coding and 56 toxin-coding unigenes belonging to 22 protein families. Three protein families, three-finger toxins (3-FTx), phospholipase A2 (PLA2), and cysteine-rich secretory protein, were detected in the venom proteome. 3-FTx (27.15% in the transcriptome/41.94% in the proteome) and PLA2 (59.71%/49.36%) were identified as the most abundant families in the venom-gland transcriptome and venom proteome. In addition, 24 unigenes from 11 protein families were shown to have experienced positive selection in their evolutionary history, whereas four were relatively conserved throughout evolution. Commercial Naja atra antivenom exhibited a stronger capacity than Bungarus multicinctus antivenom to immunocapture H. curtus venom components, especially short neurotoxins, with the capacity of both antivenoms to immunocapture short neurotoxins being weaker than that for PLA2s.ConclusionsOur study clarified the venom-gland transcriptomic and venomic profiles along with the within-group divergence of a H. curtus population from the South China Sea. Adaptive evolution of most venom components driven by natural selection appeared to occur rapidly during evolutionary history. Notably, the utility of commercial N. atra and B. multicinctus antivenoms against H. curtus toxins was not comprehensive; thus, the development of species-specific antivenom is urgently needed.

Dataset Information

The complete mitochondrial genome of a yellow-bellied sea snake (Hydrophis platurus) (Squamata, Elapidae).

Publications

The complete mitochondrial genome of a yellow-bellied sea snake (<i>Hydrophis platurus</i>) (Squamata, Elapidae).

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets