Neuronal timescales are functionally dynamic and shaped by cortical microarchitecture.

ABSTRACT: Complex cognitive functions such as working memory and decision-making require information maintenance over seconds to years, from transient sensory stimuli to long-term contextual cues. While theoretical accounts predict the emergence of a corresponding hierarchy of neuronal timescales, direct electrophysiological evidence across the human cortex is lacking. Here, we infer neuronal timescales from invasive intracranial recordings. Timescales increase along the principal sensorimotor-to-association axis across the entire human cortex, and scale with single-unit timescales within macaques. Cortex-wide transcriptomic analysis shows direct alignment between timescales and expression of excitation- and inhibition-related genes, as well as genes specific to voltage-gated transmembrane ion trans

SUBMITTER: Gao R 

PROVIDER: S-EPMC7755395 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature