Style transfer with variational autoencoders is a promising approach to RNA-Seq data harmonization and analysis.

ABSTRACT:

Motivation

The transcriptomic data are being frequently used in the research of biomarker genes of different diseases and biological states. The most common tasks there are the data harmonization and treatment outcome prediction. Both of them can be addressed via the style transfer approach. Either technical factors or any biological details about the samples which we would like to control (gender, biological state, treatment, etc.) can be used as style components.

Results

The proposed style transfer solution is based on Conditional Variational Autoencoders, Y-Autoencoders and adversarial feature decomposition. To quantitatively measure the quality of the style transfer, neural network classifiers which predict the style and semantics after training on real expression were u

SUBMITTER: Russkikh N 

PROVIDER: S-EPMC7755413 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature