Clinical and Economic Evaluation of the Impact of Midazolam on Morphine Therapy for Pain Relief in Critically Ill Ventilated Infants with Respiratory Distress Syndrome.

ABSTRACT:

Background

The impact of midazolam on the overall performance of morphine therapy for pain in ventilated neonates with respiratory distress syndrome (RDS) has never been investigated.

Objective

This study is a clinical and economic analysis of morphine monotherapy versus morphine plus midazolam in ventilated infants with RDS.

Methods

A decision-analytic model from the hospital perspective was developed to follow the consequences of the use of the study drugs. Clinical and resource utilization data were extracted based on a retrospective cohort study of 104 neonates with RDS receiving morphine alone versus in combination with midazolam at the main neonatal intensive care unit (NICU) in Qatar, from 2014 to 2019. Primary outcome measures were the analgesia success rate,

SUBMITTER: Abushanab D 

PROVIDER: S-EPMC7755454 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature