Different mutations in SARS-CoV-2 associate with severe and mild outcome.

ABSTRACT:

Introduction

Genomic alterations in a viral genome can lead to either better or worse outcome and identifying these mutations is of utmost importance. Here, we correlated protein-level mutations in the SARS-CoV-2 virus to clinical outcome.

Methods

Mutations in viral sequences from the GISAID virus repository were evaluated by using "hCoV-19/Wuhan/WIV04/2019" as the reference. Patient outcomes were classified as mild disease, hospitalization and severe disease (death or documented treatment in an intensive-care unit). Chi-square test was applied to examine the association between each mutation and patient outcome. False discovery rate was computed to correct for multiple hypothesis testing and results passing FDR cutoff of 5% were accepted as significant.

Results

Mutat

SUBMITTER: Nagy A 

PROVIDER: S-EPMC7755579 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature