Morphometric Changes to Corneal Dendritic Cells in Individuals With Mild Cognitive Impairment.

ABSTRACT:

Purpose

There has been increasing interest in identifying non-invasive, imaging biomarkers for neurodegenerative disorders of the central nervous system (CNS). The aim of this proof-of-concept study was to investigate whether corneal sensory nerve and dendritic cell (DC) parameters, captured using in vivo confocal microscopy (IVCM), are altered in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD).

Methods

Fifteen participants were recruited from the Australian Imaging Biomarkers and Lifestyle (AIBL) study in Melbourne, VIC, Australia. The cohort consisted of cognitively normal (CN) individuals (n = 5), and those with MCI (n = 5) and AD (n = 5). Participants underwent a slit lamp examination of the anterior segment, foll

SUBMITTER: Dehghani C 

PROVIDER: S-EPMC7755610 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature