Burden of disease associated with X-linked hypophosphataemia in adults: a systematic literature review.

ABSTRACT: This systematic review collated evidence on the burden of XLH in adults. Data captured highlight the substantial ongoing burden of XLH in adulthood and identified unmet needs. Greater awareness and understanding of the impact of XLH in adulthood are needed to improve care and outcomes in adults with XLH.

Introduction

X-linked hypophosphataemia (XLH) is a rare metabolic bone disease characterized by renal phosphate wasting and musculoskeletal manifestations. Whilst the disease's impact in children is well documented, information on the effects of this progressive, debilitating condition on adults is lacking. This systematic review aimed to collate existing evidence on the burden of XLH in adulthood to identify unmet needs.

Methods

MEDLINE, Embase and Cochrane Library databases

SUBMITTER: Seefried L 

PROVIDER: S-EPMC7755619 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature