Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.

ABSTRACT: Expression of abnormally long polyglutamine (polyQ) tracks is the source of a range of dominant neurodegenerative diseases, such as Huntington disease. Currently, there is no treatment for this devastating disease, although some chemicals, e.g., metformin, have been proposed as therapeutic solutions. In this work, we show that metformin, together with salicylate, can synergistically reduce the number of aggregates produced after polyQ expression in Caenorhabditis elegans. Moreover, we demonstrate that incubation polyQ-stressed worms with low doses of both chemicals restores neuronal functionality. Both substances are pleitotropic and may activate a range of different targets. However, we demonstrate in this report that the beneficial effect induced by the combination of these drugs depends

SUBMITTER: Gomez-Escribano AP 

PROVIDER: S-EPMC7755709 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature