Gestational perfluoroalkyl substance exposure and body mass index trajectories over the first 12 years of life.

ABSTRACT:

Background/objectives

Gestational exposure to perfluoroalkyl substances (PFAS), a ubiquitous class of persistent endocrine disrupting chemicals, is associated with increased risk of obesity and cardiometabolic disease. However, it is unclear if gestational PFAS exposure is associated with adiposity trajectories related to adult obesity and cardiometabolic health.

Subjects/methods

We measured perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), perfluorononaoic acid, and perfluorohexanesulfonic acid (PFHxS) concentrations in maternal serum collected between 16 weeks gestation and delivery in a cohort of 345 mother-child pairs in Cincinnati, OH (enrolled 2003-06). From age 4 weeks to 12 years, we measured weight and length or height up to eight times and calcula

SUBMITTER: Braun JM 

PROVIDER: S-EPMC7755727 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature