Tau PET imaging with ¹⁸F-PI-2620 in aging and neurodegenerative diseases.

ABSTRACT:

Purpose

In vivo measurement of the spatial distribution of neurofibrillary tangle pathology is critical for early diagnosis and disease monitoring of Alzheimer's disease (AD).

Methods

Forty-nine participants were scanned with ¹⁸F-PI-2620 PET to examine the distribution of this novel PET ligand throughout the course of AD: 36 older healthy controls (HC) (age range 61 to 86), 11 beta-amyloid+ (Aβ+) participants with cognitive impairment (CI; clinical diagnosis of either mild cognitive impairment or AD dementia, age range 57 to 86), and 2 participants with semantic variant primary progressive aphasia (svPPA, age 66 and 78). Group differences in brain regions relevant in AD (medial temporal lobe, posterior cingulate cortex, and lateral parietal cortex) were examined u

SUBMITTER: Mormino EC 

PROVIDER: S-EPMC7755737 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature