Protein Ligand-Induced Amplification in the 1/f Noise of a Protein-Selective Nanopore.

ABSTRACT: Previous studies of transmembrane protein channels have employed noise analysis to examine their statistical current fluctuations. In general, these explorations determined a substrate-induced amplification in the Gaussian white noise of these systems at a low-frequency regime. This outcome implies a lack of slowly appearing fluctuations in the number and local mobility of diffusing charges in the presence of channel substrates. Such parameters are among the key factors in generating a low-frequency 1/f noise. Here, we show that a protein-selective biological nanopore exhibits a substrate-induced amplification in the 1/f noise. The modular composition of this biological nanopore includes a hydrophilic transmembrane protein pore fused to a water-soluble binding protein on its

SUBMITTER: Sun J 

PROVIDER: S-EPMC7755739 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature