Evaluation of miR-130 family members as circulating biomarkers for the diagnosis of bladder cancer.

ABSTRACT:

Objective

Previous research has shown that the miR-130 family is closely related to the occurrence and development of bladder cancer. We hope to use the miR-130 family members as new, non-invasive, and easily detectable biomarkers for bladder cancer.

Methods

We analyzed 428 cases in The Cancer Genome Atlas-Bladder Urothelial Carcinoma database and verified that the miR-130 family members were significantly overexpressed in bladder cancer. A total of 74 bladder cancer patients and 90 controls were enrolled. The relative expression of the miR-130 family in serum was detected using quantitative reverse transcription-polymerase chain reaction. The diagnostic efficacy of the miR-130 family members was determined using the receiver operating characteristic method (ROC), and a diag

SUBMITTER: Wang J 

PROVIDER: S-EPMC7755799 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature