Association between circular RNA expression content and severity of coronary atherosclerosis in human coronary artery.

ABSTRACT:

Background

Circular RNAs (circRNAs) may act as biomarkers of coronary artery disease (CAD). However, the relationship between expression characteristics of circRNAs and coronary atherosclerosis has not been fully explored. The aim of this study was to determine and characterize the circRNAs from human coronary artery.

Methods

The coronary artery segments were obtained from an 81-year-old male patient with sudden death of myocardial infarction at autopsy. The coronary stenosis and atherosclerosis were evaluated by hematoxylin and eosin (H&E) staining, and the circRNAs expression profile was characterized by RNA sequencing (RNA-seq). The differentially expressed circRNAs were validated by qRT-PCR.

Results

The analysis of H&E staining indicated that coronary atherosclero

SUBMITTER: Hou C 

PROVIDER: S-EPMC7755800 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature