Hypoxia and perfusion in breast cancer: simultaneous assessment using PET/MR imaging.

ABSTRACT:

Objectives

Hypoxia is associated with poor prognosis and treatment resistance in breast cancer. However, the temporally variant nature of hypoxia can complicate interpretation of imaging findings. We explored the relationship between hypoxia and vascular function in breast tumours through combined ¹⁸F-fluoromisonidazole (¹⁸ F-FMISO) PET/MRI, with simultaneous assessment circumventing the effect of temporal variation in hypoxia and perfusion.

Methods

Women with histologically confirmed, primary breast cancer underwent a simultaneous ¹⁸F-FMISO-PET/MR examination. Tumour hypoxia was assessed using influx rate constant K_i and hypoxic fractions (%HF), while parameters of vascular function (K^trans, k_ep, v_e

SUBMITTER: Carmona-Bozo JC 

PROVIDER: S-EPMC7755870 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature