Alteration of Cortical and Subcortical Structures in Children With Profound Sensorineural Hearing Loss.

ABSTRACT: Profound sensorineural hearing loss (SNHL) is an auditory disability associated with auditory and cognitive dysfunction. Due to distinct pathogenesis, some associated structural and functional changes within the brain have been investigated in previous studies, but whole-brain structural alterations are incompletely understood. We extended the exploration of neuroanatomic differences in whole-brain structure in children with profound SNHL who are primarily users of Chinese sign language (CSL). We employed surface-based morphometry (SBM) and subcortical analyses. T1-weighted magnetic resonance images of 26 children with profound SNHL and 27 age- and sex-matched children with normal hearing were analyzed. Compared with the normal control (NC) group, children with profound SNHL showed diverse

SUBMITTER: Qu H 

PROVIDER: S-EPMC7756106 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature