Effect of Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation on Patient-Reported Quality of Life: The RATE-AF Randomized Clinical Trial.

ABSTRACT:

Importance

There is little evidence to support selection of heart rate control therapy in patients with permanent atrial fibrillation, in particular those with coexisting heart failure.

Objective

To compare low-dose digoxin with bisoprolol (a β-blocker).

Design, setting, and participants

Randomized, open-label, blinded end-point clinical trial including 160 patients aged 60 years or older with permanent atrial fibrillation (defined as no plan to restore sinus rhythm) and dyspnea classified as New York Heart Association class II or higher. Patients were recruited from 3 hospitals and primary care practices in England from 2016 through 2018; last follow-up occurred in October 2019.

Interventions

Digoxin (n = 80; dose range, 62.5-250 μg/d; mean dose, 161 μg/d) or

SUBMITTER: Kotecha D 

PROVIDER: S-EPMC7756234 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature