Pd-Catalyzed Directed Thiocyanation Reaction by C-H Bond Activation.

ABSTRACT: The Pd-catalyzed directed thiocyanation reaction of arenes and heteroarenes by C-H bond activation was achieved. In the presence of an electrophilic SCN source, this original methodology offered an efficient tool to access a panel of functionalized thiocyanated compounds (21 examples, up to 78 % yield). Post-functionalization reactions further demonstrated the synthetic utility of the approach by converting the SCN-containing molecules into value-added scaffolds.

SUBMITTER: Gao M 

PROVIDER: S-EPMC7756308 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature