The factor VIII treatment history of non-severe hemophilia A.

ABSTRACT:

Background

In patients with non-severe hemophilia A, we lack detailed knowledge on the timing of treatment with factor VIII (FVIII) concentrates. This knowledge could provide information about the expected treatment timing in patients with severe hemophilia A treated with non-replacement therapies.

Objective

To assess the FVIII treatment history in patients with non-severe hemophilia A.

Methods

Patients with non-severe hemophilia (baseline FVIII activity [FVIII:C] 2-40 IU/dL) were included from the INSIGHT study. The primary outcome was median age at first FVIII exposure (ED1). In a subgroup of patients for whom more detailed information was available, we analyzed the secondary outcomes: median age at first 20 EDs, annualized bleeding rate for all bleeds (ABR), joint

SUBMITTER: Abdi A 

PROVIDER: S-EPMC7756346 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature