An Organometallic Gold(I) Bis-N-Heterocyclic Carbene Complex with Multimodal Activity in Ovarian Cancer Cells.

ABSTRACT: The organometallic Au^I bis-N-heterocyclic carbene complex [Au(9-methylcaffeine-8-ylidene)₂ ]⁺ (AuTMX₂ ) was previously shown to selectively and potently stabilise telomeric DNA G-quadruplex (G4) structures. This study sheds light on the molecular reactivity and mode of action of AuTMX₂ in the cellular context using mass spectrometry-based methods, including shotgun proteomics in A2780 ovarian cancer cells. In contrast to other metal-based anticancer agents, this organogold compound is less prone to form coordinative bonds with biological nucleophiles and is expected to exert its drug effects mainly by non-covalent interactions. Global protein expression changes of treated cancer cells revealed a multimodal mode of action of AuTMX₂

SUBMITTER: Meier-Menches SM 

PROVIDER: S-EPMC7756355 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature